Background: Today laparoscopic cholecystectomy (LC) is the gold standard treatmentof gall bladder diseases all over the world. Patients undergoing laparoscopiccholecystectomy must be the focus when planning a hospital discharge process bygiving them effective practical discharge guidelines that will increase their confidencein managing their care at home, so that, Aim: of the present study was to developdischarge guidelines for patients undergoing laparoscopic cholecystectomy. Design: Adescriptive exploratory design was utilized in this study. Setting: The study wasconducted at the surgical departments and out patients` clinics ofGastroenterologyCenter at MansouraUniversity. Sample: A purposive sample of 200adult patients, from both genders underwent laparoscopic cholecystectomy from theabove mentioned setting within 6 months. Tools for data collection: 1) A structureinterviewing questionnaire sheet to assess patients` knowledge. 2) An observationalchecklist to assess patients' practices at pre / postoperative period.3) Health conditionassessment sheet to assess patients` health condition on 1st follow up visit at outPatient's clinic. Results: The mean age of the studied patients was 43.25 ± 11.01. Morethan half (62.0%) of studied patients had unsatisfactory level of knowledge as regardslaparoscopic cholecystectomy surgery as (pre/post-operative care and dischargeinstructions). Most (90.5%) of them had unsatisfactory level of practices as(pre/postoperative practices) added to poor health condition assessment for more than half(60.0%) of the studied sample Conclusion: There was a statistical significant relationbetween patients` total knowledge scores and the total practices scores as regards theirsocio-demographic characteristics. Moreover, a highly positive correlation wasindicated between patients` knowledge & practices and their health conditionassessment. Recommendations: Further research studies are needed to focus onstudying factors affecting quality of life for patients undergoing laparoscopiccholecystectomy.