EFFECT OF DIRECT ACTING ANTIVIRAL (SOFOSBUVIR) ON DAILY LIVING ACTIVITIES OF PATIENTS WITH HEPATITIS C VIRUS

Document Type : Original Article

Authors

1 faculty of nursing port said university in port said city

2 Assistant Professor of medical surgical Nursing, Faculty of Nursing, Port Saied University

3 medical surgical nursing ,faculty of nursing,port said university

Abstract

Background: chronic hepatitis C virus is a major cause of liver-related morbidity and mortality and is known to impair activities of daily living. Direct-acting antivirals have demonstrated high efficacy to achieve sustained virological response in chronic hepatitis C patients. Aim: This study aimed to assess effect of direct acting antiviral treatment on daily living activities for patients with hepatitis C virus. Setting: This study conducted at El-Mataria Daqahlia Health insurance hospital in El-Mataria city, Daqahlia and EL-Tadamon Hospital in Port –Said city. A descriptive sample of 100 male and female adult patients were included in the study.  Tools of data collection: Three tools were used to collect study data. First tool is a questionnaire used to assess patient's demographic data, medical and surgical history, the second tool is care dependency scale used to assess level of patient dependency and third tool was daily living scale to assess daily living activities of the study patients. Results: the study results revealed that the majority of sample 73%were dependent as an effect of treatment mostly in activities which need more effort or more cognitive abilities as housekeeping and learning ability while 27% were independent independent mainly in personal activities as continence, getting dressed and undressed. Conclusion. The majority of the sample were nearly independent in personal ADL and physical activities, while about one fourth one- fourth were dependent in other activities which need more effort or more cognitive. Recommendations: Assessment of patient physical, psychological, social and spiritual health behaviors should be a part of routine patient's health assessment. Further study is recommended in a larger sample with considering factors could affecting patient's response to viral hepatitis treatment. 
 
 

Keywords

References

AbdEllatef, M. A. B., & Mohamed, A, T., (2019): Effect of Health Education program on Life Style of Patients with Hepatitis C Virus Receiving Sovaldi Combination Therapy. Vol. 6, Issue 1, pp: 933-943 ‏
Abdel salam,E.,F,.A.,(2016):Activities of daily living among patients with chronic HepatitisC Virus. Published master thesis. Ain Shams Uni;Fac. Nursing ,Pp38-45
Abd-Elsalam, S., Sharaf-Eldin, M., Soliman, S., Elfert, A., Badawi, R., & Ahmad, Y. K. (2018): Efficacy and safety of sofosbuvir plus ribavirin for treatment of cirrhotic patients with genotype 4 hepatitis C virus in real-life clinical practice. Archives of virology, 163(1), 51-56.
Ahmed, M. (2018). Era of direct acting anti-viral agents for the treatment of hepatitis C. World journal of hepatology, 10(10), 670.‏
Attia, D., El Saeed, K., Elakel, W., El Baz, T., Omar, A., Yosry, A., ... & Doss, W. (2018): The adverse effects of interferon‐free regimens in 149 816 chronic hepatitis C treated Egyptian patients. Alimentary Pharmacology & Therapeutics, 47(9), 1296-1305.‏
Crusse, E. P., & Kent, V. P. (2015): Get the facts: Hepatitis C. Nursing made Incredibly Easy, 13(5), 40-49.‏
Dijkstra, A., Buist, G., & Dassen, T. (1996): Nursing‐care dependency: development of an assessment scale for demented and mentally handicapped patients. Scandinavian Journal of Caring Sciences, 10(3), 137-143.‏
Dowsett, L. E., Coward, S., Lorenzetti, D. L., MacKean, G., & Clement, F. (2017): Living with hepatitis C virus: a systematic review and narrative synthesis of qualitative literature. Canadian Journal of Gastroenterology and Hepatology, 2017.‏
Dusheiko, G. (2017). The impact of antiviral therapy for hepatitis C on the quality of life: a perspective. Liver International, 37, 7-12.‏
El-Gendi,S.,M.,(2018):Impact of structured nursing protocol on minimizing selected side effects of Sovaldi among hepatitis c virus patients at Kafer El-sheikh liver institute . Published doctolalr thesis. Mansoura Uni;Fac. Nursing ,Pp49-54.
El Malky, M. E., Gahsh, N. E., & Atia, M. M. (2016): The effectiveness of nursing intervention program on emotional distress, self-efficacy, and liver enzymes among hepatitis C virus patients undergoing antiviral treatment therapy (sovaldi medication). American Journal of Nursing, 5(3), 72-84.‏‏
El-Maksoud, M. M. A., El-Mohsen, A. S. A., Talhat, T., & Abdalla, N. (2015): Nursing Intervention for Changing the Lifestyle of Chronic Hepatitis C. journal of Nursing and Health Science; 4(4), 75-83.‏
Evon, D. M., Stewart, P. W., Amador, J., Serper, M., Lok, A. S., Sterling, R. K., ... & Reau, N. (2018): A comprehensive assessment of patient reported symptom burden, medical comorbidities, and functional well being in patients initiating direct acting antiviral therapy for chronic hepatitis C: Results from a large US multi-center observational study. PloS one, 13(8), e0196908.‏
Graf, C. (2008). The Lawton instrumental activities of daily living scale. AJN The American Journal of Nursing, 108(4), 52-62.‏
Ioannou, G. N., Green, P. K., Beste, L. A., Mun, E. J., Kerr, K. F., & Berry, K. (2018): Development of models estimating the risk of hepatocellular carcinoma after antiviral treatment for hepatitis C. Journal of hepatology, 69(5), 1088-1098.
James, S., Ziviani, J., & Boyd, R. (2014): A systematic review of activities of daily living measures for children and adolescents with cerebral palsy. Developmental Medicine & Child Neurology, 56(3), 233-244.‏
Juanbeltz, R., Martínez-Baz, I., San Miguel, R., Goñi-Esarte, S., Cabasés, J. M., & Castilla, J. (2018): Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients. PloS one, 13(10), e0205277.‏
Juanbeltz, R., Castilla, J., Martínez-Baz, I., O'Leary, A., Sarobe, M., & San, R. M. (2019). Health-related quality of life in hepatitis C patients who achieve sustained virological response to direct-acting antivirals: a comparison with the general population. Quality of life research: an international journal of quality of life aspects of treatment, care and rehabilitation, 28(6), 1477-1484.
Kesen, O., Kani, H. T., Yanartaş, Ö., Aykut, U. E., Gök, B., Gündüz, F., ... & Alahdab, Y. Ö. (2019). Evaluation of depression, anxiety and quality of life in hepatitis C patients who treated with direct acting antiviral agents. The Turkish Journal of Gastroenterology, 30(9), 801.‏
Lohrmann, C., Dijkstra, A., & Dassen, T. (2003): Care dependency: testing the German version of the care dependency scale in nursing homes and on geriatric wards. Scandinavian Journal of Caring Sciences, 17(1), 51-56.‏
Mohamed, D., Hasab, A., El-Hassafy, M., & El-Nimr, N. (2016): Treatment Response of Chronic Hepatitis C Patients and Health-Related Quality of Life. Journal of High Institute of Public Health, 46(1), 15-24.‏
Rezik, S, (2012): assessment knowledge for patients with chronic hepatitis (c) receiving interferon therapy, Published master thesis, medical-surgical nursing, faculty of nursing, Benha University. P.p (79-84)10.
Rizk, S., M., A., (2015). Impact of educational program on quality of life in Hepatitis C infected patients treated by pegylated interferon and ribavirin. Published Doctoral thesis .Port Said Uni;Fac. Nursing ,Pp.
Smeltzer S.,C., &Bare B.,G., (2013): Bruner and Saddarth's text Book of Medical Surgical Nursing, 13th ed., Lippincott Williams Philadelphia Co., U.S.A., P.p. 1075, 1101-1113.)
Tawfeek, G. A., El-Deib, A. E. R., Attia, F. M., El-Nemr, N., Faisal, A. S., & Faisal, A. S. (2020): Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients. Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(3), 287-293.
Younossi, Z. M., Stepanova, M., Esteban, R., Jacobson, I., Zeuzem, S., Sulkowski, M., ... & Hunt, S. (2017). Superiority of interferon-free regimens for chronic hepatitis C: the effect on health-related quality of life and work productivity. Medicine, 96(7)5914.‏
Zalai, D., Carney, C. E., Sherman, M., Shapiro, C. M., & McShane, K. (2016). Fatigue in chronic hepatitis C infection: Understanding patients' experience from a cognitive‐behavioural perspective. British journal of health psychology, 21(1), 157-172.‏
Zwakhalen, S. M., Hamers, J. P., Metzelthin, S. F., Ettema, R., Heinen, M., de Man‐Van Ginkel, J. M., ... & Schuurmans, M. J. (2018): Basic nursing care: The most provided, the least evidence based–A discussion paper. Journal of clinical nursing, 27(11-12), 2496-2505.

Files

Share

How to cite

Statistics